Figure 4. Coevolution of spatially remote and proximal pairs of residues in H3 suggest a function of the buried H3 residues independent of mediating stability.

Significantly coevolving pairs of residues are shown in stick representation with dotted line between their Cβ atoms. Buried/interface residues are colored blue, while the rest of the protein is colored in grey and shown using the cartoon representation. The dotted lines between residues that are spatially proximal are colored orange, while the dotted lines between spatially distant residues are colored blue. The structure was rendered using PyMOL (http://www.pymol.org).