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. 2010 Dec 20;108(1):191–196. doi: 10.1073/pnas.1005011108

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Fig. 5. — Concurrent administration of a low-phosphate diet prevents disappearance of the growth plate. H&E (Upper) and Safranin O (Lower) staining of longitudinal cross-sections of tibiae in PPR^fl/fl (A and C) and Coll2-CreER^T:PPR^fl/fl (B and D) mice at 4 wk of age at 6 d after Tam administration. PPR^fl/fl (A and C) and Coll2-CreER^T: PPR^fl/fl (B and D) mice were fed a control diet (A and B) or a low-phosphate (P) diet (C and D) from 28 to 35 d of age. (E) Statistical analysis of the length of the columnar proliferating (Left) and hypertrophic (Right) regions of the proximal growth plate of the tibiae in PPR^fl/fl and Coll2-CreER^T:PPR^fl/fl mice fed a control or P diet. White bars represent PPR^fl/fl mice, and black bars represent Coll2-CreER^T:PPR^fl/fl mice. *P < 0.05, significantly different from PPR^fl/fl mice fed a control diet; ^#P < 0.05, significantly different from the value obtained in Coll2-CreER^T:PPR^fl/fl mice fed a control diet. Data are representative of experiments performed on sections from three or more mice for each condition.