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4E-BP1 alters proliferation and sensitivity to discodermolide-induced senescence. (A) Immunoblot of 4E-BP1 expression in A549 and AD32 tranduced with lentivirus. (B) SA-β-galactosidase activity. Cells were treated with either DMSO (vehicle) or disco (32 nM) for 4 d and then fixed and stained. Percentage positive for β-galactosidase staining (±SEM) is indicated below the respective images.
