Fig. 3.

Re-expression of 4E-BP1 increases proliferation rate and discodermolide sensitivity in a tumor xenograft model. (A) Mice bearing A549, AD32, or AD32^4E-BP1 xenografts were treated with three weekly doses (arrows) of disco (10 mg/kg i.v.), and tumor volume was calculated. Data are expressed as the percentage of change in tumor volume (T₀) ± SEM of five mice per group. Mice treated with disco are indicated by dashed lines. (B) Immunohistochemistry for K_i-67 in formaldehyde-fixed tumor xenografts.