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(A) The enzymes CbiXL, CbiXS, and CbiK catalyse the insertion of Co(II) in cobalamin biosynthesis and SirB and HemH the insertion of Fe(II) in siroheme and heme biosynthesis, respectively. (B) The ancestral homodimer, has duplicated and fused to give the larger chelatases. (C) The reaction catalysed by cobalto-chelatase is presented, metal is inserted and two protons removed from the pyrrole rings.
