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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Transpl Int. 2010 Sep 6;24(2):175–183. doi: 10.1111/j.1432-2277.2010.01160.x

Fig. 4. Regulation of blood glucose levels and body weight in diabetic rats after islet transplantation.

Fig. 4

(a) Shown are animals with small intestinal islet transplants (Group 1, -●-) and intraportal islet transplants (Group 2, -○-) to indicate return of blood glucose levels to <200 mg/dl in both groups. Control STZ-treated diabetic rats without islet transplantation (-▼-) are shown for comparison. Note that hyperglycemia promptly recurred when islet-bearing intestinal segments were removed in animals (arrow), p<0.05, which confirmed that glycemic control was due to transplanted islets. (b) Showing gains in body weight in treated animals after improvement in hyperglycemia. (c) Shows normalization of glucose tolerance tests in diabetic rats after transplantation of islets into either intestinal segment (-●-) or portal vein (-○-). Nondiabetic healthy rats (-▼-) and control STZ-treated diabetic rats (-△-) are shown for comparison.