Pyruvate dehydrogenase complexes |
(PDC) |
|
E1a decarboxylase |
41 |
Decarboxylates pyruvate with thiamine pyrophosphate (TTP) as a co-factor |
E1b decarboxylase |
36 |
Decarboxylates pyruvate with TTP as a co-factor |
E2 acetyltransferase |
74 |
Transfers acetyl group from E1 to coenzyme A (CoA) |
E3 lipoamide dehydrogenase |
55 |
Regenerates disulphide of E2 by oxidation of lipoic acid |
E3 binding protein (protein X) |
56 |
Anchoring E2 to the E2 core of pyruvate dehydrogenase complex |
|
2-oxoglutarate dehydrogenase complex |
(OGDC) |
|
E1 oxoglutarate dehydrogenase |
113 |
Decarboxylates a-ketoglutarate with TTP as a co-factor |
E2 succinyl transferase |
48 |
Transfers succinyl group from E2 to CoA |
E3 lipoamide dehydrogenase |
55 |
Regenerates disulphide of E2 by oxidation of lipoic acid |
|
Branched-chain 2-oxo-acid dehydrogenase complex |
(BCOADC) |
|
E1a decarboxylase |
46 |
Decarboxylates a-keto acids |
E1b decarboxylase |
38 |
Derived from leucine, isoleucine, and valine with TTP as a co-factor |
E2 acyltransferase |
52 |
Transfers acyl group from E1 to CoA |
E3 lipoamide dehydrogenase |
55 |
Regenerates disulphide of E2 by oxidation of lipoic acid |