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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Immunol Cell Biol. 2010 Nov 16;89(1):40–44. doi: 10.1038/icb.2010.132

Figure 2. Model of T cell activation by APC under steady state conditions or during a viral infection.

Figure 2

Under steady state conditions, CD8+ T cells are deleted by eTACs, FRCs, and hematopoetic DC, while CD4+ T cells proliferate and become anergic. Upon TLR3 engagement by virus-derived, double stranded RNA, FRCs may decrease self antigen presentation while hematopoetic DCs mature to activate T cells.