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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Clin Cancer Res. 2010 Nov 18;17(1):89–99. doi: 10.1158/1078-0432.CCR-10-1934

Fig. 5.

Fig. 5

Transport of erlotinib, A and OSI-420, B by human organic ion transporters. Results are shown for drug accumulation in HEK293 cells after 5 minutes incubation in each cell line. Columns represent (mean ± SD) 8 to 18 observations per expressed transporter, and are expressed as percentage of their respective control (white bar). Only one control bar is shown for clarity purposes. The contribution of each transporter towards erlotinib or OSI-420 uptake was established by comparing data obtained in HEK293 cells overexpressing the transporter and HEK293 cells transfected with an empty vector.* P < 0.05; ** P < 0.01; *** P < 0.001 versus control, one-way ANOVA was performed followed by a post Dunnett test.