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Proposed model for the role of efflux and uptake transporters in erlotinib CNS penetration. A, schematic diagram for endothelial cells with transporters localized on either apical border (facing blood) or basolateral border (facing brain ECF). B, schematic diagram of the choroid plexus forming the BCSFB. Transporters are localized on either the apical border (facing CSF) or basolateral border (facing blood). The arrows represent the direction of drug transport.
