Table I. Inhibition of BPDE-induced NFκB and AP-1 activity by fractions of the ethanol and water extracts of freeze-dried black raspberries^a,^b.

Ethanol fractions					Water fractions
HPLC fraction no.	NFκB activity		AP-1 activity		HPLC fraction no.	NFκB activity		AP-1 Activity
	Concentration of fraction in 0.1% DMSO (μg/ml)					Concentration of fraction in 0.1% DMSO (μg/ml)
	50	10	50	10		50	10	50	10
	% Inhibition relative to BPDE (2 μM) and no added fraction					% Inhibition relative to BPDE (2 μM) and no added fraction
1a	−19.1	−1.2	NTc	NT	1a and 1b	14.5	9.3	−4.0	1.0
1b	2.9	8.3	NT	NT
1c	17.6	6.0	5.0	3.6	1c	32.7	11.2	30.0	−20.0
1d	−44.1	40.5	24.8	−19.3	1d	53.6	45.8	0.0	−4.0
1e	26.5	46.4	0.0	−9.6	1e	75.5	65.4	56.0	6.0
1f and 1g	67.6	31.0	25.7	−3.6	1f and 1g	81.8	50.5	76.0	42.0
2a	63.2	81.0	25.7	9.6	2	73.6	55.1	48.0	6.0
2b	45.6	77.4	26.7	−26.5
3a	52.9	36.9	18.8	−2.4	3a	65.5	44.9	48.0	25.0
3b	45.6	−15.5	32.7	−20.5	3b and 3c	72.7	67.3	89.0	50.0
3c	70.6	64.3	57.4	0.0
4a	42.6	60.7	5.9	−30.1	4a	81.8	51.4	68.0	35.0
4b	95.6	60.7	77.2	26.5	4b	80.0	29.9	76.0	45.0
					4c	75.5	48.6	79.0	41.0
5	100.0	83.3	96.0	51.8	5	93.6	57.9	92.0	63.0
6	100.0	52.4	91.1	53.0	6	99.1	50.5	93.0	72.0
7a	94.7	63.3	97.0	68.7	7a	83.6	22.4	94.0	61.0
7b	57.9	43.3	34.7	1.2	7b	87.3	57.9	82.0	51.0
7c	30.3	17.8	11.8	−13.3	7c	97.3	72.0	88.5	55.1
8a	100.0	76.7	91.4	65.1	8a	97.3	70.7	82.7	24.5
8b	67.1	34.4	24.7	−19.3	8b	98.2	66.7	73.1	10.2
8c	27.6	51.1	26.9	6.0	8c	64.5	28.0	−48.1	−63.3
9a	26.3	34.4	41.9	−6.0	9	91.8	78.7	57.7	−10.2
10a	50.0	17.8	50.5	9.6	10a	63.6	25.3	−117	−143
10b	86.8	65.6	77.4	44.6	10b	40.0	33.3	−140	−131
10c	100.0	72.2	81.7	73.5	10c	70.0	30.7	−50.0	−85.7
10d	14.5	16.7	−6.5	−34.9	10d	61.8	−5.3	−137	−139
10e	−5.3	41.1	8.6	−2.4	10e	56.4	−6.7	−129	−116
10f	5.3	12.2	65.6	30.1	10f	51.8	−34.7	−148	−155
10g	15.8	34.4	−21.5	−31.3

^aSee Materials and methods for details of NFκB and AP-1 assays.

^bHighlighted fractions had >50% inhibitory activity for at least one concentration in both assays.

^cNT, not tested.