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. Author manuscript; available in PMC: 2011 Jan 7.
Published in final edited form as: Biol Cell. 2010;102(10):561–580. doi: 10.1042/BC20100038

Figure 4. Site-Specific Recombinases (SSRs).

Figure 4

A, If two sites of a SSR are in relative proximity on the DNA in opposite orientations, SSR-mediated recombination between these two sites results in an inversion of the DNA fragment between the two sites (upper panel). If the two sites are in the same orientation, SSR-mediated recombination between these two sites results in an excision of the DNA fragment between the two sites, and the appearance of a circular DNA corresponding to this excised fragment (lower panel). B, SSRs frequently used in gene targeting, and their corresponding sites.