Table 2.
Genetic loci associated with HTG.
| Locus | SNP | CHR | Position | Minor Allele | HTG MAF | Control MAF | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|---|---|
| APOA5 | rs964184 | 11 | 116.2 | G | 0.33 | 0.14 | 3.28 (2.61-4.14) | 5.4 × 10-24 |
| GCKR | rs1260326 | 2 | 2.8 | T | 0.52 | 0.41 | 1.75 (1.45-2.12) | 6.5 × 10-9 |
| LPL | rs7016880 | 8 | 19.9 | C | 0.03 | 0.10 | 0.32 (0.21-0.49) | 2.0 × 10-7 |
| APOB | rs4635554 | 2 | 21.2 | G | 0.39 | 0.31 | 1.67 (1.38-2.02) | 2.0 × 10-7 |
| | ||||||||
| MLXIPL | rs714052 | 7 | 72.5 | G | 0.07 | 0.13 | 0.44 (0.31-0.62) | 0.000003 |
| TRIB1 | rs2954029 | 8 | 126.6 | T | 0.37 | 0.46 | 0.71 (0.59-0.86) | 0.0004 |
| ANGPTL3 | rs10889353 | 1 | 62.9 | C | 0.27 | 0.32 | 0.73 (0.59-0.89) | 0.002 |
| NCAN | rs17216525 | 19 | 19.5 | T | 0.07 | 0.09 | 0.71 (0.50-1.00) | 0.05 |
| FADS | rs174547 | 11 | 61.3 | C | 0.40 | 0.33 | 1.20 (0.99-1.44) | 0.07 |
| XKR6 | rs7819412 | 8 | 11.1 | G | 0.46 | 0.50 | 0.87 (0.72-1.05) | 0.14 |
| PLTP | rs7679 | 20 | 44.0 | C | 0.20 | 0.19 | 1.17 (0.94-1.47) | 0.16 |
CHR, chromosome; CI, confidence interval; HTG, hypertriglyceridemia; MAF, minor allele frequency; OR, odds ratio; SNP, single nucleotide polymorphism. Association was tested using an additive multivariate logistic regression model, entering sex, body mass index, diabetes status, and 10 principal components of ancestry as covariates. The top four loci surpassed a pre-specified threshold for genome-wide significance of P<5×10-7. Remaining loci were replicated from GWAS meta-analysis of population-based TG concentrations5, using a Bonferroni corrected significance threshold of P<0.005.