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. 2010 Oct 5;19(1):159–164. doi: 10.1038/mt.2010.212

Figure 2.

Figure 2

Antisense-induced myostatin exon 2 skipping with 2'OMePS oligomers leads to an increase in C2C12 cell proliferation. C2C12 cells were treated with a range of 2'OMePS oligomers along with lipofectamine 2000 (LF2000), and assayed 24 hours later for cell proliferation by lactic dehydrogenase assay. Treatment with 2'OMePS oligomers A3, B3, and D3 resulted in significant increases in the number of cells after 24 hours compared to the cultures treated with only transfection reagent LF2000 but no AO. C3 did not induce a substantial change. (t-test analysis, n = 6; *P < 0.05; **P < 0.01). 2'OMePS, 2'O-methyl phosphorothioate RNA.