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. 2010 Oct 19;19(1):46–52. doi: 10.1038/mt.2010.217

Figure 2.

Figure 2

Effects of delayed DN-TNF gene transfer on nigral DA neuron survival. Total numbers of TH and NeuN double-positive cells at 2 and 5 weeks after 6-OHDA lesion were estimated by unbiased stereology and analyzed using a one-way analysis of variance. Data are reported as the mean ± SEM. Fisher's post hoc test was used to assess significance. Bars with different letters are statistically significantly different from each other (P < 0.05). Group N's: saline/GFP–5 weeks (n = 6); 6-OHDA– 2 weeks (n = 5); 6-OHDA/GFP–5 weeks (n = 7); 6-OHDA/DN-TNF–5 weeks (n = 9). DA, dopaminergic; DN-TNF, dominant-negative tumor necrosis factor; GFP, green fluorescent protein; NeuN, neuronal nuclei; 6-OHDA, 6-hydroxydopamine; TH, tyrosine hydroxylase.