Figure 1.
Oncolytic properties of VSV in vitro and in vivo. (a) MTT assays were performed on AE17ova cells infected with various MOI of VSV-GFP (data as percentage of control cell survival ± s.d). (b) Virus titers were determined from AE17ova cells infected with VSV-GFP at indicated MOIs. (c) Six-day AE17ova tumors in C57Bl/6 mice were injected with PBS or VSV-GFP every 2 days for four injections. Survival (tumors reaching a size of 1.0 cm in any diameter) is shown with time. GFP, green fluorescent protein; MOI, multiplicity of infection; PBS, phosphate-buffered saline; VSV, vesicular stomatitis virus.