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. 2010 Oct 26;19(1):140–149. doi: 10.1038/mt.2010.224

Figure 2.

Figure 2

CPA has antitumor activity in the AE17ova model. (a) Six-day AE17ova tumor-bearing C57Bl/6 mice were treated with CPA (3 mg/mouse, i.p.) or PBS followed by intratumoral VSV-GFP 24 hours later (n = 3/group). 15 minutes after injection (0 hours), 24, 48, 72, or 96 hours later, virus from tumor lysates was tittered on BHK-21 cells (total pfu of VSV/tumor). (b) Six-day AE17ova tumor-bearing C57Bl/6 mice were treated with CPA (3 mg/mouse, i.p.) or PBS followed by intratumoral PBS or VSV-GFP 24 hours later (n = 7/group). This cycle of CPA/VSV was repeated two times, every 6 days. Survival is shown with time. Data is representative of three different experiments. CPA, cyclophosphamide; i.p., intraperitoneal; PBS, phosphate-buffered saline; VSV, vesicular stomatitis virus.