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. Author manuscript; available in PMC: 2011 Jan 7.
Published in final edited form as: J Biol Chem. 2006 Mar 13;281(19):13169–13179. doi: 10.1074/jbc.M601010200

FIGURE 9. Possible mechanisms by which multiple D-sites could interact to bind JNK.

FIGURE 9

For clarity, only two D-sites are shown. A, additive interaction, in which the individual D-sites bind to the same region of JNK. B, synergistic interaction, in which the different D-sites bind weakly to distinct regions of JNK. C, an example of a partially additive, partially synergistic mechanism. In this example, the basic submotif of D1 interacts preferentially with the CD region of JNK, whereas the hydrophobic submotif of D2 interacts preferentially with the hydrophobic docking groove of JNK. If an individual D-site is absent, residues from another D-site can fill its slot, although not with the same affinity.