Table 1.
Pfmdr1 and pfatpase6 haplotypes from Paragominas (PRG), Porto Velho (PV) and Manaus (MAN) isolates.
| Gene | Haplotypes | n (n/locality) | % | Mutated codons |
|---|---|---|---|---|
|
pfmdr1 (n = 85) |
NEF/CDVY | 82 (19/PRG, 33/PV, 30/MAN) | 97 | 4 |
| NEF/SDVY | 1 (MAN) | 1 | 3 | |
| YEY/SNVD | 1 (MAN) | 1 | 1 | |
| NEY/SNVD | 1 (MAN) | 1 | 0 | |
|
pfatpase6 (n = 65) |
HLLE/AAGNKKSK | 24 (6/PRG, 4/PV, 14/MAN) | 37 | 0 |
| HLLE/ASGNKKSK | 23 (11/PRG, 12/MAN) | 35 | 1 | |
| HLVE/AAGNKKSK | 3 (PV) | 5 | 1 | |
| HLVE/ASGNKKSK | 15 (PV) | 23 | 2 | |
Codon positions: pfmdr1 N86Y, E130K, Y184F, S1034C, N1042 D, V1109I, D1246Y (n = 85); pftapase6 H243Y, L263E, L402V, E431K, A623E, A630 S, G639 D, N683K, K716R, K776N, S769N, K771E (n = 65). The haplotype of 3D7 strain is underlined and the mutated codons are shown in bold characters.