Figure 5.

Image from a patient with autosomal dominant RP. The background is an infra-red SLO image from the Heidelberg Spectralis. The line indicates the location of the SD-OCT scan, which goes through fixation. The SD-OCT scan shows that photoreceptors are preserved in the central macula only with attenuation of outer retinal layers beginning about 6 degrees eccentric to fixation, and also reveals the presence of mild cystoid macular edema, or CME. A reduced-scale AOSLO montage is aligned and superimposed on the background image. The insets are full scale-sections of the AOSLO montage at two locations indicated by the black squares. The left inset is from the advancing front of degeneration, and RPE cells are clearly seen as a polygonal network of cells comprising the left half of the image. Some irregularly distributed cones are still visible on the right side of the image, albeit at a lower density than normal. The right inset is of the foveal region. Small white squares indicate the locus of fixation. Cones are resolved across most of the field, and are lower density than would be found in a normal eye. The dark lines and shadows in the inset do not indicate where cones are lost, but rather are formed by capillaries and the boundaries of the cystic spaces. It is presumed that preserved and functioning cones are likely to be present beneath these shadows, although cones are not clearly seen. Scale bar for the inset is 1 degree.