Table 2. Entropy difference, with randomization test, between severe and mild sequence populations for A/H1N1pdm viruses sampled in Canada (during Wave 1 only).
| Nucleotide Positiona | Protein Position | AA Consensus (Mild/Severe) | AA Variance (Mild/Severe) | P-Valueb | E-Scorec | |
| 01 | PB2-1438 | PB2-480 | V (105/25) | I (1/3) | 0.030 | 0.029 |
| 02 | PB1-473 | PB1-158 | N (92/28) | S (12/0) | 0.010 | 0.069 |
| 03 | HA-604 | HA-203 | S (77/27) | T (28/1) | 0.010 | 0.009 |
| 04 | HA-879 | HA-293 | Q (76/13) | H (28/11) | 0.030 | 0.140 |
| 05 | NA-1180 | NA-394 | V (91/28) | I (14/0) | 0.010 | 0.041 |
| 06 | NS1-164 | NS1-55 | E (106/26) | G (0/2) | 0.040 | 0.042 |
a
Nucleotide position on the coding sequence of each genome segment;
b
P values were calculated from the randomization test on entropy score differences between severe and mild sequence populations;
c
E-Scores were calculated from Fisher Exact Test; <0.05 highlighted in bold font.