Table 3.

Sequences of selected peptides and summary of their activities against HIV-1 TAR RNA (K_d values are in nM), as determined by EMSA in the presence of competitor tRNA

Mimetic	Position																Kd (nM)	Error (nM)
	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16
KP-Z-01	R	V	R	C	R	K	L	K	G	Q	T	R	C	I	R	I	>5000
KP-Z-02	R	V	R	C	R	K	R	DR	G	Q	T	R	C	I	R	I	75	±25
KP-Z-03	R	V	R	C	R	Q	R	G	P	G	K	R	C	I	R	I	>5000
KP-Z-04	R	V	R	C	R	K	Q	G	P	G	T	R	C	I	R	I	>5000
KP-Z-05	R	V	R	C	R	R	K	G	P	G	Q	R	C	I	R	I	150	±50
KP-Z-06	R	V	R	C	R	K	R	G	P	G	Q	R	C	I	R	I	>5000
KP-Z-07	R	C	R	V	R	Q	R	K	G	R	A	R	K	I	C	I	150	±50
KP-Z-08	R	C	R	V	R	K	Q	G	P	G	T	R	K	I	C	I	>5000
KP-Z-09	R	C	R	V	R	K	Q	G	P	G	K	R	K	I	C	I	>5000
KP-Z-10	R	C	R	V	R	K	R	G	P	G	Q	R	K	I	C	I	>5000
KP-Z-11	R	C	R	V	R	R	K	G	P	G	A	R	K	I	C	I	200	±50
KP-Z-12				R	V	R	C	R	R	R	G	R	C	I	R	I	>5000
KP-Z-13				R	V	R	C	R	K	K	DP	K	C	I	R	I	>5000
KP-Z-14				R	V	R	T	R	K	K	DP	K	R	I	R	I	750
KP-Z-15				R	V	R	V	R	K	K	G	R	T	I	R	I	>5000
KP-Z-16			R	V	R	C	R	K	R	K	G	R	C	I	R	I	500
KP-Z-17			R	V	R	C	R	R	K	R	G	R	C	I	R	I	300
KP-Z-18			R	V	R	T	R	Q	R	K	G	R	R	I	R	I	200	±50
KP-Z-19			R	V	R	V	R	K	R	K	G	R	Q	I	R	I	250	±50
KP-Z-20			R	V	R	Q	R	K	R	K	G	R	V	I	R	I	200	±50
KP-Z-21			R	V	R	C	R	K	R	K	DP	R	C	I	R	I	300
KP-Z-22	R	V	R	C	R	T	R	G	K	R	R	R	C	A	R	V	200	±50
KP-Z-33	R	V	R	C	R	K	R	R	G	Q	T	R	C	I	R	I	100	±25
KP-Z-34	R	V	R	C	R	K	R	K	G	Q	T	R	C	I	R	I	100	±25
KP-Z-35	R	V	R	T	R	K	R	DR	G	Q	T	R	A	I	K	I	150	±50
KP-Z-36	R	C	R	V	R	K	R	DR	G	Q	T	R	R	I	C	I	200	±50
KP-Z-37	R	C	R	V	R	R	K	K	G	R	A	R	K	I	C	I	200	±50
KP-Z-38	R	C	R	V	R	Q	R	G	P	G	A	R	K	I	C	I	>1000
KP-Z-39	R	V	R	C	R	T	R	K	G	R	A	R	C	I	K	I	75	±25
KP-Z-40	R	V	R	C	R	Q	R	K	G	R	R	A	C	I	R	I	25	±10
KP-Z-41	R	V	R	C	R	Q	R	K	G	R	R	I	C	I	R	I	75	±25

All peptides are cyclized with a D-Pro-L-Pro motif not listed here to simplify the table.

Lower-case letters indicate D-amino acids.