Table 1.
Comparisons of binding site annotations provided by the curated datasets and M-ORBIS
| Datasets | Sensitivity (IR) | Lower bound specificity (IR) | Pearson correlationa | Manually curated interfaceb | M-ORBIS interfacec | Interacting surfaced |
|---|---|---|---|---|---|---|
| Homodimer (18) | 99.7 | 86.4 | 0.98 | 26.8 (12.8) | 31.8 (15.4) | 33.8 (16) |
| Heterodimer (27) | 96.5 | 68.3 | 0.97 | 19.1 (9) | 32.8 (23.6) | 39.9 (18.5) |
| RNA (19) | 98.2 | 85.7 | 0.99 | 18.4 (8.3) | 21.4 (9.7) | 28.2 (16) |
| DNA (22) | – | – | 0.99 | – | 26.8 (11) | 40.3 (26.5) |
The sensitivity corresponds to the fraction of residues that are inferred as interacting by M-ORBIS, among all the interacting residues described in each curated dataset. The lower bound specificity is the precision at which a residue described as interacting by M-ORBIS was annotated as such in the curated datasets. Numbers in parenthesis are standard deviations.
aA Pearson correlation indicates the resemblance between the IR compositions calculated from the curated and M-ORBIS analysis.
bThe fractions of interacting surface described by the curated analysis.
cThe fractions of interacting surface described by M-ORBIS
dThe interacting surface corresponds to the surface involved in at least one non-solvent interaction.