Table 2.
Average functional landscape of protein structures
| Dataset | Homodimer | Heterodimer | Peptide | S.Peptide | DNA | RNA | Ligand | Solvant | Int.Surface |
|---|---|---|---|---|---|---|---|---|---|
| SWD10 | 26.5 (13.5) | 28.2 (14) | 16.9 (5.9) | 10.7 (6.5) | 20.6 (8.2) | 19.8 (9.4) | 14.7 (8.6) | 86.5 (11.7) | 43.9 (16.1) |
| SWD25 | 23.4 (10.9) | 21.7 (9.1) | 16.6 (5.7) | 9.2 (5.1) | 18.7 (7.6) | 18 (8.3) | 9.9 (4.8) | 78.5 (14.5) | 37.6 (12.8) |
| SWD50 | 19.2 (8.5) | 17.4 (8) | 15.3 (5.4) | 8.1 (3.8) | 17.5 (7.6) | 16.8 (7.6) | 7.1 (4.2) | 58.4 (17.9) | 31.9 (11.1) |
| SWD75 | 16.6 (9.2) | 14.1 (6.9) | 11.9 (5.7) | 6.9 (2.8) | 15 (6.7) | 15 (7) | 5.1 (4.3) | 30 (16.9) | 26.7 (9.8) |
| SWD90 | 15.3 (8.9) | 11.4 (6.5) | 11.2 (5.8) | 5.6 (2.5) | 12.6 (5.9) | 13.6 (5.4) | 4.6 (4.4) | 15.1 (13.3) | 23.6 (9.6) |
| SWD90/SWD10 (%) | 58 | 40 | 66 | 52 | 61 | 69 | 31 | 17 | 54 |
Each line described the average fractions of protein surface involved in each interaction type for a given fcontact. These fractions have been computed on the SWD dataset for fcontact of 10, 25, 50, 75 and 90%, respectively. The contribution of a structure to each fraction of interacting surface was considered only when it presented the given interaction type. The ratio SWD90/SWD10 indicates the percentage of frequently interacting residues for a given binding site type. Numbers in parenthesis are standard deviations.