Table 3.

Amino acid composition/contribution of the specific versus polyvalent binding sites

Residue	HoD (A)	HoD,HoD (B)	Log(B/A)	HoD,HeD (C)	Log(C/B)	HoD,Solvent(D)	Log(D/B)	DNA	HoD,DNA
GLY	6.3	7.2	0.05	5.4	−0.12	6.2	−0.07	5.3	2.6
ALA	6.5	9.2	0.15	4.4	−0.32	5.8	−0.20	4.2	2.1
VAL	5.5	10.5	0.28	5.2	−0.31	4.1	−0.41	6.0	11.3
LEU	8.8	17.1	0.29	7.5	−0.36	6.3	−0.43	3.5	6.7
ILE	4.8	10.2	0.33	2.8	−0.56	3.2	−0.51	3.9	4.6
PRO	5.1	8.0	0.20	3.4	−0.38	4.3	−0.27	3.5	3.1
MET	2.6	4.2	0.22	2.8	−0.18	2.1	−0.31	4.9	8.7
PHE	4.4	6.9	0.20	8.0	0.07	3.5	−0.29	0.9	0.0
TRP	1.6	1.1	−0.16	1.3	0.07	1.7	0.18	0.4	0.0
SER	5.7	3.3	−0.24	8.0	0.38	6.4	0.29	9.7	6.2
THR	5.6	4.0	−0.14	6.7	0.22	6.1	0.18	8.8	8.7
ASN	4.2	1.5	−0.45	2.8	0.27	5.0	0.52	7.2	6.2
GLN	4.4	1.9	−0.37	3.4	0.25	5.2	0.44	4.6	5.6
ASP	5.8	1.9	−0.49	5.2	0.43	7.0	0.57	4.6	2.6
GLU	6.8	2.3	−0.47	6.7	0.47	8.1	0.55	4.1	5.1
CYS	1.2	1.5	0.09	0.5	−0.47	1.1	−0.13	0.9	0.0
TYR	4.2	2.6	−0.22	7.7	0.48	4.7	0.26	2.8	1.5
HIS	3.3	1.5	−0.33	2.3	0.18	3.8	0.39	2.7	3.1
LYS	6.1	3.1	−0.30	10.6	0.54	7.1	0.37	12.7	11.3
ARG	6.9	1.9	−0.56	5.4	0.45	8.4	0.65	9.2	10.8
Hydrophob	39.7	66.5		31.4		31.9		31.3	39.1
Anionic	12.6	4.2		11.9		15.1		8.7	7.7
Cationic	13	5		16		15.5		21.9	22.1
Polar	19.9	10.7		20.9		22.7		30.3	26.7
C(HoD)	0.97	0.64		0.61		0.76		0.45	0.49
C(HeD)	0.86	0.17		0.77		0.90		0.77	0.6
C(Pcore)	0.43	0.93		0.17		−0.07		−0.11	0.17
C(Crystal)	0.84	0.10		0.62		0.95		0.67	0.5

C(X) is a Pearson product–moment correlation between the amino acid scale described in column and the published amino acid scale X. When X is HoD (homodimer), the amino acid scale is from Bahadur et al. (18); when X is HeD (Heterodimer) or Pcore (protein core), the amino acid scales are from Albou et al. (27); when X is Crystal (crystal packing), it is from Bahadur et al. (15). HoD,X (such as HoD,HeD) indicates an homodimer/X polyvalent binding site.