Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Sep 7;39(1):300–312. doi: 10.1093/nar/gkq761

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 1. — A mechanistic model of –1 programmed ribosomal frameshifting. Two translation elongation cycles are depicted at the top: the ribosome undergoes decoding (DC), aa-tRNA accommodation (AA), peptidyltransfer (PT) and translocation (TL) twice to add two amino acids into the polypeptide sequences. A shift in reading frame may occur at the first TL step and the ribosome decodes a −1 frame A-site codon at the recoding site. Additionally, −1 PRF may occur during the second AA step, in which the ribosome has decoded the zero frame A-site codon. Incorporation of the −1 reading frame aa-tRNA starts at the following cycle. Moreover, the shift in reading frame may occur at the second TL step and incorporation of the −1 reading frame aa-tRNA starts at the following cycle.