Table 1.
Representative examples of PPARβ/δ target genes regulated by TGFβ-mediated repression and reversal by GW501516 (class A genes)
| Gene | Gene product | TGFβa | GW501516a | (GW501516 + TGFβ) / TGFβb |
|---|---|---|---|---|
| ANGPTL4 | Angiopoietin-like 4 | 0.3 | 6.5 | 18.9 |
| PDK4 | Pyruvate dehydrogenase kinase, isozyme 4 | 0.4 | 4.7 | 4.1 |
| CPT1A | Carnitine palmitoyltransferase 1A | 0.5 | 2.0 | 3.2 |
| DDEF1IT1 | DDEF1 intronic transcript 1 | 0.7 | 1.5 | 2.8 |
| GPR137B | G-protein-coupled receptor 137B | 0.4 | 1.6 | 2.6 |
| SP100 | SP100 nuclear antigen | 0.5 | 1.3 | 2.5 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.5 | 1.4 | 2.3 |
| IMPA2 | Inositol(myo)-1(or 4)-monophosphatase 2 | 0.3 | 1.7 | 2.2 |
| ACAA2 | Acetyl-Coenzyme A acyltransferase 2 | 0.7 | 1.4 | 2.0 |
| ABCA1 | ATP-binding cassette, sub-family A, member 1 (cholesterol transporter) | 0.6 | 1.5 | 1.9 |
| ADRP | Adipose differentiation-related protein | 0.4 | 1.8 | 1.9 |
| CAT | Catalase | 0.4 | 1.5 | 1.8 |
aRelative expression values derived from microarray data (fold induction relative to solvent-treated cells).
bValues reflect GW501516-mediated induction in the presence of TGFβ corrected for the TGFβ effect.