Table 1.

Differentially expressed glycoproteins between the undifferentiated and differentiated HSR-GBM1 cells.

Accession	Protein name	Gene	Location	Ratioa	p-valueb
PGCB_HUMAN	Brevican core protein	BCAN	Membrane	8.27	1.54E-09
GGH_HUMAN	Gamma-glutamyl hydrolase	GGH	Extracellular	7.65	2.90E-07
CATD_HUMAN	Cathepsin D	CTSD	Lysosome	4.10	3.35E-07
EGFR_HUMAN	Epidermal growth factor receptor	EGFR	Membrane	NAc	1.19E-06
LYAG_HUMAN	Lysosomal alpha-glucosidase	GAA	Lysosome	25.73	8.96E-06
BGAL_HUMAN	Beta-galactosidase	GLB1	Lysosome	12.54	5.04E-05
SAP_HUMAN	Proactivator polypeptide	PSAP	Lysosome	4.12	5.57E-05
PTPRZ_HUMAN	Receptor-type tyrosine-protein phosphatase zeta	PTPRZ1	Membrane	0	0.00011
PPGB_HUMAN	Lysosomal protective protein	CTSA	Lysosome	6.44	0.00025
PLOD1_HUMAN	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	ERd	0.17	0.00031
LG3BP_HUMAN	Galectin-3-binding protein	LGALS3BP	Extracellular	21.84	0.00041
NAGAB_HUMAN	Alpha-galactosidase B	NAGA	Lysosome	NA	0.00059
APMAP_HUMAN	Adipocyte plasma membrane -associated protein	APMAP	Membrane	4.331	0.0018
ARSA_HUMAN	Arylsulfatase A Precursor	ARSA	Lysosome	NA	0.0056
HEXA_HUMAN	Beta-hexosaminidase subunit alpha	HEXA	Lysosome	NA	0.0061
P4HA1_HUMAN	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	ER	0	0.0075
LAMP2_HUMAN	CD107b antigen	LAMP2	Lysosome & membrane	8.00	0.0089
TENA_HUMAN	Tenascin-C	TNC	Extracellular	0	0.0097

^aThe ratio of the spectral index of a target protein identified from differentiated HSR-GBM1 cells to that identified from undifferentiated HSR-GBM1 neurosphere.

^bp-value: statistical significance of differentially expressed proteins between differentiated and undifferentiated HSR-GBM1 cells. The values were generated by Student’s t-test for six replicate experiments. The differential expression of a protein was considered to be significant if the p-value was less than 0.01.

^cNA means the protein was only identified from differentiated HSR-GBM1 cells.

^dER represents endoplasmic reticulum.