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Reduced levels of merlin and increased MLK3 activity in human tumor cell lines. (a and b) Whole cell extracts from tumor cells were prepared at low confluence (panel a) or confluent (panel b) and subjected to Western blotting with p-MLK3 (Thr277/Ser281) antibody which detects active MLK3 enzyme. Cell extracts were also subjected to immunoblotting with MLK3 and merlin antibodies. Arrows indicate Ser518 hyperphosphorylated (upper band) or hypophosphorylated (lower band) forms of merlin.
