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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: J Immunol. 2010 Nov 1;185(11):7097–7106. doi: 10.4049/jimmunol.1002751

FIG. 9.

FIG. 9

Similar SIV envelope evolution of virus variants in plasma and breast milk samples during chronic SIV infection. (A) The median number of acquired mutations in the virus envelope of plasma (filled box) and breast milk (unfilled box) virus variants are similar in all three monkeys. The results from paired, nonparametric t testing of the median number of plasma and milk virus envelope mutations are as follows: monkey 206 at week 74, 23 blood virus variants and 21 milk virus variants (P = 0.5); monkey 402 at week 67, 22 blood virus variants and 18 milk virus variants (P = 0.19); and monkey 403 at week 48, 20 blood virus variants and 15 milk virus variants (P = 0.67). (B) The frequency of acquired amino acid mutations in the SIV envelope gene product is similar in plasma (closed symbol) and breast milk (open symbol) virus variants from chronic infection in three monkeys. The frequency of an amino acid mutation is graphed as a function of amino acid position within the envelope. Envelope variable regions 1 to 5 (V1 to −5) are indicated. Amino acid positions with no mutations in all virus variants were not plotted.