Figure 1.

TNFR-KO mice are hypersusceptible to early phases of Salmonella infection. (A) Survival of WT and congenic TNFR-KO mice was recorded over time after infection with roughly 10³ colony-forming units of virulent 12023 or attenuated sseB mutant S. typhimurium. (B) The bacterial burden present in livers of WT and TNFR-KO mice was measured after 1 and 3 days of Salmonella infection. The data represent the mean ± SEM of six to 14 mice from three independent experiments.