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Absence of TNFR increases the survival of sseB mutant Salmonella in macrophages. Killing of Salmonella by untreated or IFN-γ-treated macrophages from WT and TNFR-KO mice is shown after 20 (A) or 2 h (B) of challenge. Salmonella-infected macrophages from TNFR-KO mice produced similar or greater quantities of superoxide (C) and nitrite (D) as WT control macrophages. The data represent the mean ± SEM of six to 30 independent experiments. *P < 0.001, **P < 0.03 compared with WT controls.
