Table 1.

Time course of morphologic changes post TNF-α treatment^a

Time post-treatment	Inflammatory infiltrateb	Hemorrhagec	Thrombosis & Congestiond	Tumor Necrosise
Ctr	-	-	-	-
4hr	++++	+++	++	+
Day 1	+++	-	++	+++
Day 3	+	-	+	+++
Day 7	+	-	+	++

^aData correspond to semi-quantitative evaluation in tumor areas of hematoxylin-eosin sections (evaluation was made in five representative fields per sample under 20^× magnification]. Three to four independent experiments were performed for each treatment.

^bAverage numbers of leukocytes per field.

^cPercent of tissue area involved by hemorrhage.

^dAverage number of vessels affected by congestion/dilation and thrombosis per field.

^ePercent of tumor area involved by necrosis.