Table 4.
Differentially expressed (DE) genes in the expression profile of 'Fully Resistant' animals 72 hours post-inoculation
| Genes grouped by function | Genbank human RefSeq ID | FR v C fold change | FR v S fold change |
|---|---|---|---|
| More highly expressed in 'Fully Resistant' animals | |||
| Extracellular matrix components | |||
| Collagen, type I, alpha 1 (COL1A1) | NM_000088 | +2.55 | +3.94 |
| Periostin (POSTN) | NM_006475 | +1.84 | +3.16 |
| Immunoglobulin | |||
| Immunoglobulin alpha heavy chain constant region (IGHA) | NONE | +2.03 | +1.82 |
| Retinoid-binding | |||
| Cellular retinoic acid binding protein 2 (CRABP2) | NM_001878 | +1.97 | +2.23 |
| Other | |||
| Mortality factor 4 like 1 (MORF4L1) | NM_206839 | +1.75 | +2.64 |
| Less highly expressed in 'Fully Resistant' animals | |||
| Retinoid binding | |||
| Apolipoprotein D (APOD) | NM_001647 | -2.04 | -4.59 |
| Retinol binding protein 4 (RBP4) | NM_006744 | -2.36 | -4.92 |
| PPAR-γ regulators/regulated | |||
| Thioredoxin interacting protein (TXNIP) | NM_006472 | -1.87 | -2.43 |
| Nuclear protein 1 (NUPR1) | NM_012385 | -2.06 | -1.75 |
| Pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4) | NM_002612 | -2.33 | -1.89 |
| Lipid mobilization and metabolism | |||
| ATP-binding cassette, sub-family A, member 6 (ABCA6) | NM_172346 | -2.69 | -2.81 |
| Other | |||
| Ubiquitin-conjugating enzyme E2L 6 (UBE2L6) | NM_004223 | -1.78 | +2.63 |
| Annexin A8 like 2 (ANXA8L2) | NM_001630 | -1.84 | -2.73 |
| Pre-mRNA cleavage complex II protein (PCF2) | NM_015885 | -1.84 | -3.27 |
| Proprotein convertase subtilisin/kexin type 6 (PCSK6) | NM_138319 | -1.85 | -2.91 |
| Glutathione S-transferase M3 (GSTM3) | NM_000849 | -1.91 | -1.99 |
| BTG family, member 2 (BTG2) | NM_006763 | -1.92 | -2.85 |
| Calnexin (CANX) | NM_001746 | -2.30 | -2.03 |
| Thymosin like 3 (TMSL3) | NM_183049 | -5.28 | -4.86 |
| Porcine endogenous retrovirus type C (PERV-C) | NONE | -7.11 | -3.41 |
A list of all DE genes identified in both the FR v C and FR v S comparisons 72 hours post-inoculation. Gene names were assigned on the basis of the best sequence match to a human gene identified by BLAST. Genes highlighted in bold are annotated with the 'GO' terms listed in the Results section. Genes not in bold type face were identified as having a particular function through literature searches. Genes are arranged in groups of related function. Fold changes are expressed with respect to the 'FR' animals. Gene expression was either higher (+) or lower (-) in 'FR' animals compared to 'Control' and 'Susceptible' animals (BH corrected p < 0.05).