. Author manuscript; available in PMC: 2011 Jan 10.

Published in final edited form as: Clin Pharmacol Ther. 2010 May 26;88(1):95–100. doi: 10.1038/clpt.2010.62

Table 3.

Univariate analysis (Cox Model) of the influence of the different variables studied on graft loss.

Variable	Category²	Hazard ratio	CI 95%	p
*6986 A>G (CYP3A5**3)	AG vs GG	2.437	0.867–6.850	0.0910
*−392 A>G (CYP3A4***1B)*	AG vs AA	0.913	0.121–6.896	0.9299
*ABCB1 1236 C>T*	TT vs CC	8.403	1.733–41.667	0.0083
*ABCB1 1236 C>T*	CT vs CC	1.825	0.705–4.717	0.2149
*ABCB1 2677 G>T*	TT vs GG	10.417	2.105–52.631	0.0041
*ABCB1 2677 G>T*	GT vs GG	2.174	0.829–5.682	0.1143
*ABCB1 3435 C>T*	TT vs CC	3.921	1.059–14.493	0.0407
*ABCB1 3435 C>T*	CT vs CC	1.211	0.313–4.695	0.7820
*ABCB1 haplotype 1236 C>T/2677 G>T/3435 C>T*	TTT vs CGC¹	2.616	1.373–4.986	0.0035
*Age recipient*	per year increase	0.995	0.965–1.026	0.7496
*Age donor*	per year increase	1.030	0.995–1.067	0.1254
*Sex recipient*	Female vs Male	0.806	0.329–1.977	0.6398
*Sex donor*	Female vs Male	0.885	0.360–2.178	0.7906
*Acute rejection*	≥1 vs 0	2.756	1.095–6.933	0.0321
*Cold ischemia time*	per min. increase	0.999	0.998–1.001	0.3218
*Total HLA mismatch*	per mismatch increase	0.885	0.629–1.245	0.4851

Estimation of the risk when carrying the mutated allele vs. the wild type allele calculated with THESIAS

For the most frequent category of the variable, taken as reference, HR=1.