Table 2.
Hematological parameters of male and female rats on subchronic toxicity study.
| (a) Male | (b) Female | |||||||
|---|---|---|---|---|---|---|---|---|
| Parameter | Vehicle control | YMJ-500 mg | YMJ-1000 mg | YMJ-2000 mg | Vehicle control | YMJ-500 mg | YMJ-1000 mg | YMJ-2000 mg |
| WBC (×103/μL) | 12.10 ± 1.04 | 10.72 ± 1.06 | 10.49 ± 0.48 | 10.83 ± 0.58 | 8.74 ± 0.71 | 8.54 ± 0.72 | 7.56 ± 0.71 | 9.33 ± 0.91 |
| Reticulocytes (%) | 2.1 ± 0.1 | 2.3 ± 0.2 | 2.0 ± 0.1 | 2.3 ± 0.1 | 1.9 ± 0.1 | 1.7 ± 0.1 | 1.9 ± 0.1 | 2.3 ± 0.1 |
| Neutrophils (%) | 14.46 ± 1.39 | 18.57 ± 1.82 | 21.65 ± 1.76** | 18.37 ± 1.10 | 13.07 ± 2.25 | 13.27 ± 1.57 | 15.91 ± 0.74 | 14.98 ± 2.31 |
| Lymphocytes (%) | 77.8 ± 1.6 | 74.3 ± 1.9 | 71.0 ± 1.7** | 75.1 ± 1.2 | 80.4 ± 2.2 | 79.2 ± 1.7 | 76.9 ± 0.8 | 79.1 ± 2.2 |
| Eosinophils (%) | 1.1 ± 0.1 | 1.1 ± 0.2 | 1.2 ± 0.1 | 1.1 ± 0.2 | 1.2 ± 0.2 | 1.2 ± 0.2 | 1.2 ± 0.1 | 1.1 ± 0.1 |
| Monocytes (%) | 4.7 ± 0.4 | 4.5 ± 0.3 | 4.5 ± 0.3 | 3.6 ± 0.3 | 3.6 ± 0.3 | 4.6 ± 0.7 | 4.0 ± 0.3 | 3.3 ± 0.2 |
| Basophils (%) | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.9 ± 0.1 | 0.7 ± 0.1 |
| LUC (%) | 1.3 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.1 | 1.1 ± 0.2 | 1.0 ± 0.1 | 0.9 ± 0.1 | 1.1 ± 0.2 | 0.9 ± 0.1 |
| RBC (×106/μL) | 8.63 ± 0.16 | 8.65 ± 0.13 | 8.70 ± 0.14 | 8.66 ± 0.11 | 8.19 ± 0.09 | 8.20 ± 0.13 | 8.38 ± 0.11 | 7.92 ± 0.09 |
| Hemoglobin (g/dL) | 15.7 ± 0.4 | 16.1 ± 0.1 | 16.1 ± 0.3 | 16.4 ± 0.1 | 16.1 ± 0.3 | 16.0 ± 0.3 | 16.3 ± 0.2 | 15.9 ± 0.2 |
| Hmatocrit (%) | 44.6 ± 1.0 | 45.4 ± 0.5 | 45.4 ± 0.7 | 46.0 ± 0.5 | 44.9 ± 0.6 | 44.1 ± 0.7 | 45.3 ± 0.4 | 43.8 ± 0.5 |
| MCV (fL) | 51.7 ± 0.8 | 52.5 ± 0.9 | 52.2 ± 0.7 | 53.1 ± 0.5 | 54.9 ± 0.5 | 53.8 ± 0.5 | 54.1 ± 0.4 | 55.4 ± 0.6 |
| MCH (pg) | 18.2 ± 0.3 | 18.7 ± 0.3 | 18.5 ± 0.3 | 19.0 ± 0.2 | 19.7 ± 0.2 | 19.5 ± 0.2 | 19.5 ± 0.2 | 20.1 ± 0.2 |
| MCHC (g/dL) | 35.2 ± 0.1 | 35.5 ± 0.2 | 35.4 ± 0.2 | 35.8 ± 0.2 | 35.9 ± 0.2 | 36.3 ± 0.2 | 36.0 ± 0.3 | 36.3 ± 0.3 |
| Platelet (×103/μL) | 1048 ± 24 | 1034 ± 36 | 1053 ± 36 | 1065 ± 49 | 1089 ± 48 | 1080 ± 48 | 1098 ± 20 | 1051 ± 38 |
| PT (sec) | 16.1 ± 0.4 | 15.5 ± 0.3 | 16.0 ± 0.4 | 16.8 ± 0.6 | 14.5 ± 0.2 | 14.3 ± 0.2 | 14.2 ± 0.3 | 14.1 ± 0.1 |
| APTT (sec) | 18.6 ± 0.4 | 18.8 ± 0.6 | 18.2 ± 0.4 | 18.8 ± 0.3 | 15.0 ± 0.2 | 14.8 ± 0.5 | 15.3 ± 0.4 | 15.1 ± 0.4 |
Values are mean ± SEM for 10 rats in each group. **, significant differences from the vehicle control (0) group (P < .01). WBC: white blood cells; LUC: large unstained cells; RBC: red blood cells; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; PT: prothrombin time; APTT: activated partial prothrombin time.