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. Author manuscript; available in PMC: 2011 Apr 1.

Published in final edited form as: J Mol Cell Cardiol. 2010 Jun 8;49(4):625–638. doi: 10.1016/j.yjmcc.2010.05.014

Fig. 6 — BFT boosts the pentose phosphate pathway and moderates AGE and neurohormonal activation in infarcted hearts. Bar graphs showing the effect of MI and BFT on transketolase (A) and G6PD activity (B) and AGE levels (C) in myocardium of diabetic and non-diabetic mice. Plasma and myocardial levels of angiotensin II (D) and norepinephrine (E) are also shown (n=5 mice per group, each assay performed in triplicate). Values expressed as U/min/mg of protein for transketolase and G6PD activity and absorbance (OD) for AGE levels. Angiotensin II and epinephrine levels were expressed as pg/ml or pg/gm of protein for plasma and heart respectively. All the values are mean±standard deviation. *P<0.01 and **P<0.001 versus vehicle-treated sham-operated mice and ^#P<0.01 and ^##P<0.001 versus vehicle-treated MI mice within non-diabetic or diabetic group. ^δP<0.01 and ^δδP<0.01 versus corresponding treatment between non-diabetic and diabetic group. NDS — vehicle-treated sham-operated non-diabetic; NDV — vehicle-treated non-diabetic with MI; NDB — BFT-treated- non-diabetic with MI; DS — vehicle-treated sham-operated diabetic; DV — vehicle-treated diabetic with MI; DB — BFT-treated diabetic with MI.

Fig. 6 — BFT boosts the pentose phosphate pathway and moderates AGE and neurohormonal activation in infarcted hearts. Bar graphs showing the effect of MI and BFT on transketolase (A) and G6PD activity (B) and AGE levels (C) in myocardium of diabetic and non-diabetic mice. Plasma and myocardial levels of angiotensin II (D) and norepinephrine (E) are also shown (n=5 mice per group, each assay performed in triplicate). Values expressed as U/min/mg of protein for transketolase and G6PD activity and absorbance (OD) for AGE levels. Angiotensin II and epinephrine levels were expressed as pg/ml or pg/gm of protein for plasma and heart respectively. All the values are mean±standard deviation. *P<0.01 and **P<0.001 versus vehicle-treated sham-operated mice and ^#P<0.01 and ^##P<0.001 versus vehicle-treated MI mice within non-diabetic or diabetic group. ^δP<0.01 and ^δδP<0.01 versus corresponding treatment between non-diabetic and diabetic group. NDS — vehicle-treated sham-operated non-diabetic; NDV — vehicle-treated non-diabetic with MI; NDB — BFT-treated- non-diabetic with MI; DS — vehicle-treated sham-operated diabetic; DV — vehicle-treated diabetic with MI; DB — BFT-treated diabetic with MI.