Table 1.
Demographics, body composition and distribution, serum adipokines and ghrelin levels in women with systemic autoimmune disease, in patients with Sjögren syndrome and healthy women (results are given as mean ± SEM; P 1: Man Whitney test between patients with systemic autoimmune disease and healthy controls; P 2: Man Whitney test between patients with Sjögren's syndrome and healthy controls).
| Systemic autoimmune diseases whole series (N = 15) | Sjögren syndrome (N = 7) | Healthy controls (N = 15) | P 1 | P 2 | |
|---|---|---|---|---|---|
| Age (years) | 57.7 ± 3.5 | 59.5 ± 3.7 | 54.5 ± 2.1 | NS | NS |
| Disease duration (years) | 6.5 ± 1.4 | 4.7 ± 1.1 | — | — | — |
| Clinical manifestations | Polyarthritis/arthralgia: N = 14 Myalgia N = 2 Dermatological manifestations N = 2 Sicca syndrome N = 7 Peripheral neuropathy N = 1 Pulmonary involvement N = 2 Raynaud syndrome N = 3 Renal disease N = 0 | — | — | — | — |
| BMI (kg/m2) | 29.0 ± 1.9 | 32.03 ± 3.5 | 25.4 ± 1.1 | NS | NS |
| Corticosteroid dosage (mg/day) | 6.6 ± 1.3 | 5.7 ± 2.2 | — | — | — |
| Cumulative corticosteroid dose (mg) | 11018 ± 4481 | 9192.8 ± 5349 | — | — | — |
| ESR (mm/H) | 16.3 ± 2.6 | 17.8 ± 4.6 | 14.5 ± 5.3 | NS | NS |
| CRP (mg/L) | 6.5 ± 1.9 | 5 ± 2 | 5.7 ± 1.8 | NS | NS |
| IL-6 (pg/mL) | 9.02 ±3.69 | 6.7 ± 3.2 | 0.02 ± 0.02 | .025 | .05 |
| Glycemia (mmol/L) | 4.8 ± 0.1 | 4.9 ± 0.2 | 4.6 ± 0.1 | NS | NS |
| Insulin (μIU/L) | 10.3 ± 2.05 | 12.8 ± 3.9 | 8.6 ± 1.1 | NS | NS |
| HOMA-IR | 2.14 ± 0.37 | 2.6 ± 0.6 | 1.49 ± 0.15 | NS | NS |
| Total cholesterol (g/L) | 1.88 ± 0.1 | 1.9 ± 0.2 | 1.83 ± 0.1 | NS | NS |
| LDL cholesterol (g/L) | 1.02 ± 0.1 | 1.05 ± 0.2 | 1.03 ± 0.1 | NS | NS |
| HDL cholesterol (g/L) | 0.61 ± 0.04 | 0.7 ± 0.05 | 0.57 ± 0.04 | NS | NS |
| Leptin (ng/mL) | 25.2 ± 5.6 | 31.1 ± 10.6 | 14.4 ± 3.4 | NS | NS |
| Leptin /fat mass (ng/mL/Kg) | 0.72 ± 0.1 | 0.7 ± 0.2 | 0.82 ± 0.1 | NS | NS |
| Adiponectin (μg/mL) | 16.3 ± 1.6 | 17.8 ± 2.6 | 9.7 ± 0.6 | .01 | .04 |
| Ghrelin (pg/mL) | 1118 ± 127 | 1249. 1 ± 220.5 | 1012 ± 56 | NS | NS |
| Fat mass (g) | 30140 ± 3411 | 33554.1 ± 5573.1 | 21518 ± 1862 | NS | NS |
| Lean mass (g) | 40822 ± 1348 | 42475.7 ± 2128.5 | 47011 ± 1908 | NS | NS |
| Adiposity (%) | 40.9 ± 2.3 | 42.8 ± 2.8 | 30.8 ± 1.8 | NS | NS |
| Fat in the android region (g) | 2681 ± 421 | 3099 ± 741.1 | 1951 ± 222 | NS | NS |
| Fat in the gynoid region (g) | 5710 ± 541 | 6282.9 ± 794.2 | 3905 ± 340 | NS | NS |
(ESR: erythrocyte sedimentation rate; BMI: body mass index; HOMA-IR: homeostasis model assessment index; NS: nonsignificant).