Table 1.
Systemic autoimmune diseases whole series (N = 15) | Sjögren syndrome (N = 7) | Healthy controls (N = 15) | P 1 | P 2 | |
---|---|---|---|---|---|
Age (years) | 57.7 ± 3.5 | 59.5 ± 3.7 | 54.5 ± 2.1 | NS | NS |
Disease duration (years) | 6.5 ± 1.4 | 4.7 ± 1.1 | — | — | — |
Clinical manifestations | Polyarthritis/arthralgia: N = 14 Myalgia N = 2 Dermatological manifestations N = 2 Sicca syndrome N = 7 Peripheral neuropathy N = 1 Pulmonary involvement N = 2 Raynaud syndrome N = 3 Renal disease N = 0 | — | — | — | — |
BMI (kg/m2) | 29.0 ± 1.9 | 32.03 ± 3.5 | 25.4 ± 1.1 | NS | NS |
Corticosteroid dosage (mg/day) | 6.6 ± 1.3 | 5.7 ± 2.2 | — | — | — |
Cumulative corticosteroid dose (mg) | 11018 ± 4481 | 9192.8 ± 5349 | — | — | — |
ESR (mm/H) | 16.3 ± 2.6 | 17.8 ± 4.6 | 14.5 ± 5.3 | NS | NS |
CRP (mg/L) | 6.5 ± 1.9 | 5 ± 2 | 5.7 ± 1.8 | NS | NS |
IL-6 (pg/mL) | 9.02 ±3.69 | 6.7 ± 3.2 | 0.02 ± 0.02 | .025 | .05 |
Glycemia (mmol/L) | 4.8 ± 0.1 | 4.9 ± 0.2 | 4.6 ± 0.1 | NS | NS |
Insulin (μIU/L) | 10.3 ± 2.05 | 12.8 ± 3.9 | 8.6 ± 1.1 | NS | NS |
HOMA-IR | 2.14 ± 0.37 | 2.6 ± 0.6 | 1.49 ± 0.15 | NS | NS |
Total cholesterol (g/L) | 1.88 ± 0.1 | 1.9 ± 0.2 | 1.83 ± 0.1 | NS | NS |
LDL cholesterol (g/L) | 1.02 ± 0.1 | 1.05 ± 0.2 | 1.03 ± 0.1 | NS | NS |
HDL cholesterol (g/L) | 0.61 ± 0.04 | 0.7 ± 0.05 | 0.57 ± 0.04 | NS | NS |
Leptin (ng/mL) | 25.2 ± 5.6 | 31.1 ± 10.6 | 14.4 ± 3.4 | NS | NS |
Leptin /fat mass (ng/mL/Kg) | 0.72 ± 0.1 | 0.7 ± 0.2 | 0.82 ± 0.1 | NS | NS |
Adiponectin (μg/mL) | 16.3 ± 1.6 | 17.8 ± 2.6 | 9.7 ± 0.6 | .01 | .04 |
Ghrelin (pg/mL) | 1118 ± 127 | 1249. 1 ± 220.5 | 1012 ± 56 | NS | NS |
Fat mass (g) | 30140 ± 3411 | 33554.1 ± 5573.1 | 21518 ± 1862 | NS | NS |
Lean mass (g) | 40822 ± 1348 | 42475.7 ± 2128.5 | 47011 ± 1908 | NS | NS |
Adiposity (%) | 40.9 ± 2.3 | 42.8 ± 2.8 | 30.8 ± 1.8 | NS | NS |
Fat in the android region (g) | 2681 ± 421 | 3099 ± 741.1 | 1951 ± 222 | NS | NS |
Fat in the gynoid region (g) | 5710 ± 541 | 6282.9 ± 794.2 | 3905 ± 340 | NS | NS |
(ESR: erythrocyte sedimentation rate; BMI: body mass index; HOMA-IR: homeostasis model assessment index; NS: nonsignificant).