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Impact of dosing time from −10 to 24 h on the predicted AUC ratio in the DDI between itraconazole as the inhibitor and the three substrates (A). Focus on the dosing time from −1 to 1 h (B). The increase in AUC was predicted using the dynamic model (with the inclusion of the hydroxy-itraconazole active metabolite) and with alprazolam (
), midazolam (▴) or triazolam (□) as the victim drugs, with dosing schedules as defined in the methods
