Table 2.

Input parameters for the azole inhibitors used in Simcyp simulations. Values for k_a are Simcyp defaults, where CYP3A4 K_i and fu_p data for fluconazole and ketoconazole were from [1] and itraconazole and hydroxy-itraconazole from [25]

Inhibitor	Ki (CYP3A4) (µm)	fup	ka (h−1)
Fluconazole	11.9	0.890	1.28
Ketoconazole	0.0420	0.017	1.90
Itraconazole	0.0013	0.036	0.62
Hydroxy-itraconazole	0.0144	0.0045	–