Table 3.
Comparison of predicted AUC ratios by the dynamic and static models according to the inhibitor and potency of DDI investigated. Weak, moderate and strong DDIs refer to interactions with fold increase in victim drug AUC <2, 2–5 and >5-fold, respectively
| Inhibitor | Weak DDI | Moderate DDI | Strong DDI | Total | ||||
|---|---|---|---|---|---|---|---|---|
| Dynamic : static predicted AUC ratio | >1 | <1 | >1 | <1 | >1 | <1 | >1 | <1 |
| Fluconazole | – | 1/10 | – | 9/10 | – | – | – | 10/10 |
| Itraconazole | – | – | 3/12 | 4/12 | 4/12 | 1/12 | 7/12 | 5/12 |
| Ketoconazole | – | 1/13 | – | 2/13 | 2/13 | 8/13 | 2/13 | 11/13 |
| Subtotal | – | 2/35 | 3/35 | 15/35 | 6/35 | 9/35 | 9/35 | 26/35 |
| Total | 2/35 | 18/35 | 15/35 | 35/35 | ||||