Table 4.
Accuracy of 35 DDI predictions using either the time-based dynamic or static model in Simcyp, classified according to either inhibitor or DDI potency (moderate and strong indicating 2–5 and >5-fold increase in AUC of the victim drug, respectively)
| Model | Number of studies within 2-fold (%) | Number of studies within 1.5-fold (%) | afe | rmse |
|---|---|---|---|---|
| Dynamic | ||||
| Inhibitor | ||||
| Fluconazole (n = 10) | 90 | 50 | 1.52 | 1.29 |
| Ketoconazole (n = 13) | 54 | 31 | 2.07 | 5.60 |
| Itraconazole (n = 12) | 75 | 50 | 1.46 | 2.64 |
| Potency | ||||
| Moderate (n = 18) | 78 | 50 | 1.51 | 1.54 |
| Strong (n = 15) | 60 | 27 | 1.97 | 5.57 |
| Overall* (n = 35) | 71 | 43 | 1.68 | 3.81 |
| Static | ||||
| Inhibitor | ||||
| Fluconazole (n = 10) | 100 | 100 | 1.06 | 0.96 |
| Ketoconazole (n = 13) | 62 | 54 | 1.63 | 4.95 |
| Itraconazole (n = 12) | 75 | 33 | 1.43 | 3.26 |
| Potency | ||||
| Moderate (n = 18) | 94 | 72 | 1.04 | 1.15 |
| Strong (n = 15) | 53 | 40 | 1.89 | 5.36 |
| Overall* (n = 35) | 77 | 60 | 1.34 | 3.61 |
*
Accuracy of the two weak DDIs is not displayed in the analysis according to the DDI potency but was included in the overall analysis.