Table 1.

Observed and predicted morphine clearance (CL) in children of different age groups

		Predicted CL	Predicted CL	%RMSE	%RMSE	%MPE	%MPE
Age group	Observed CL	Exp 0.75	Maturation	Exp 0.75	Maturation	Exp 0.75	Maturation
Pre-term	4.9 ± 3.6	81 ± 25	8.6 ± 5.7	1629	136	1551	82
Pre-term*	4.9 ± 3.6	81 ± 25	5.3 ± 3.5	1629	108	1551	8
Term	27 ± 23	145 ± 20	33 ± 6	446	86	431	19
1 week to 2 months	43 ± 24	167 ± 22	52 ± 10	292	45	288	21
>2–10 months	126 ± 67	222 ± 39	128 ± 47	91	59	76	1.5
3.1–5 years	562 ± 317	469 ± 40	469 ± 40	54	54	17	17

^*With adjustment factor of 0.61. MPE, mean predictive error; RSME, root mean square error.