Table 1.
Results of univariate analysis of key clinical and demographic factors in relation to Peanut IgE ≥ 5 kUA/L (additional factors described in text).
| Variable | Total (N) number of subjects | N with Peanut IgE≥5 kUA/L (%) | Odds Ratio | 95% CI | P-value |
|---|---|---|---|---|---|
| Site | 0.002 | ||||
| Denver | 96 | 22 (22.9%) | 0.92 | 0.47, 1.79 | |
| Duke | 101 | 22(21.8%) | 0.86 | 0.44, 1.67 | |
| Johns Hopkins | 108 | 47(43.5%) | 2.38 | 1.30, 4.36 | |
| Mount Sinai | 104 | 26(25.0%) | 1.03 | 0.54, 1.96 | |
| Arkansas | 94 | 23(24.5%) | reference | ||
| Sex | 0.007 | ||||
| Male | 342 | 108 (31.6%) | 1.86 | 1.19, 2.92 | |
| Female | 161 | 32 (19.9%) | reference | ||
| Race | 0.003 | ||||
| Black | 79 | 29 (36.7%) | 1.87 | 1.11, 3.13 | |
| Asian | 39 | 19 (48.7%) | 3.05 | 1.56, 5.98 | |
| Other | 14 | 4 (28.6%) | 1.29 | 0.39, 4.20 | |
| White | 371 | 88 (23.7%) | reference | ||
| Parental Allergy/Asthma | 0.339 | ||||
| No Known | 83 | 28 (33.7%) | reference | ||
| Maternal | 120 | 36 (30.0%) | 0.84 | 0.46, 1.53 | |
| Paternal | 83 | 24 (28.9%) | 0.80 | 0.41, 1.54 | |
| Both | 217 | 52 (24.00%) | 0.62 | 0.36, 1.08 | |
| AD severity | 0.005 | ||||
| None | 40 | 2 (5.0%) | reference | ||
| Mild | 50 | 10 (20.0%) | 5.00 | 1.03, 24.3 | |
| Moderate | 253 | 72 (28.5%) | 7.76 | 1.83, 32.95 | |
| Severe | 160 | 56 (35.0%) | 10.50 | 2.44, 45.1 | |
| Milk, egg or both allergy (clinical reaction) | <0.0001 | ||||
| Egg | 162 | 32 (19.8%) | 0.37 | 0.23, 0.59 | |
| Milk | 99 | 11 (11.1%) | 0.19 | 0.10, 0.37 | |
| Both | 242 | 97 (40.1%) | reference | ||
| Enrolled with AD or clinical reaction | 0.003 | ||||
| AD | 196 | 56 (28.6%) | 0.81 | 0.53, 1.23 | |
| Clinical reaction | 90 | 12 (13.3%) | 0.31 | 0.16, 0.61 | |
| Both | 217 | 72 (33.2%) | reference | ||
| Stomach Acid Control Agents | 0.036 | ||||
| Yes | 74 | 13 (17.6%) | 0.51 | 0.2700, 0.96 | |
| No | 429 | 127 (29.6%) | reference | ||
| Breastfed | 0.811 | ||||
| Yes | 174 | 48 (27.6%) | 0.85 | 0.46, 1.55 | |
| Prior to enrollment | 258 | 70 (27.1%) | 0.83 | 0.47, 1.47 | |
| Never | 71 | 22 (31.00%) | reference | ||
| Peanut present in house during breast feeding | 0.270 | ||||
| Yes | 373 | 107 (28.7%) | 1.72 | 0.86, 3.44 | |
| No | 58 | 11 (19.00%) | reference | ||
| Soy formula | 0.143 | ||||
| Yes | 243 | 75 (30.9%) | 1.34 | 0.91, 1.98 | |
| No | 260 | 65 (25.0%) | reference | ||
| Peanut consumption- pregnancy | 0.002 | ||||
| Frequent (>=2x/wk) | 211 | 74 (35.1%) | 1.85 | 1.25, 2.74 | |
| Infrequent (<2x/wk) | 292 | 66 (22.6%) | reference | ||
| Peanut consumption during breast feeding | 0.039 | ||||
| Frequent (>=2x/wk) | 129 | 45 (34.9%) | 1.57 | 1.02, 2.42 | |
| Infrequent (<2x/wk) | 374 | 95 (25.4%) | reference | ||