Table 5.

Release of antibiotics in cements

Study	Modulator*	Antibiotic(s)*	Bone cement	Release duration	Amount released persurface area	Relative release†	Relative compression strength‡
Kuechle et al. [11]	Dextran 13 g	Vancomycin 1 g	Surgical Simplex®	5 days	323 μg/cm2	355%	Not available
Mendez et al. [16]	Poly(ε-capro-lactone) 12 g	Vancomycin 0.6 g	Noncommercial	8 weeks	960 μg/cm2	314%	50%
Virto et al. [21]	Lactose 8 g	Gentamicin 1.6 g	CMW1®	8 weeks	2100 μg/cm2	457%	Not available
Current Study	Bacterial cellulose 0.5 g	Vancomycin 2.5 g & gentamicin 2.5 g	Surgical Simplex®	5 weeks	1700 μg/cm2	129%	122%

* Amount incorporated per 40 g cement powder; ^†amount released with modulator relative to amount released without modulator; ^‡compression strength with modulator relative to that without modulator.