Table 1.
Comparison of studies of GCT
| Study | Year | Followup (range) | Patients | Surgical treatment | Recurrences | Lung metastases | Factors influencing recurrence rate |
|---|---|---|---|---|---|---|---|
| Arbeitsgemeinschaft Knochentumoren [1] | 2008 | 63 months (0–421) | 256 | Wide resection Curettage Curettage + PMMA Curettage + PMMA + phenol |
2% 49% 22% 27% |
NR | Surgical margin Tumor extension PMMA |
| Balke et al. [3] | 2008 | 60 months (8–280) | 214 | Wide resection Curettage Curettage + burr Curettage + burr + PMMA Curettage + burr + PMMA + H2O2 |
0% 65% 22% 18% 12% |
3.3% | Surgical margin Tumor extension Location Burr PMMA H2O2 |
| Blackley et al. [5] | 1999 | 80 months (29–132) | 59 | Curettage + burr | 12% | 1.7% | NR |
| Campanacci et al. [6] | 1987 | 2–44 years | 280 | Wide resection Marginal excision Intralesional excision |
0% 8% 27% |
2.1% | Surgical margin |
| Errani et al. [15] | 2010 | 91 months (36–204) | 349 | Wide resection Curettage + burr + phenol Curettage + burr + phenol + PMMA |
12% 13% 18% |
4% | Location |
| Kivioja et al. [22] | 2008 | 5 years (0.2–18) | 294 | Wide/marginal resection Curettage Curettage + PMMA |
12% 51% 22% |
NR | Surgical margin PMMA Age |
| Malek et al. [29] | 2006 | 48 months (18–78) | 40 | Curettage + burr | 33% | NR | None |
| McDonald et al. [31] | 1986 | 84 months (min. 24) | 146 | Wide resection Intralesion excision ± burr |
7% 34% |
3.2% | Surgical margin |
| O’Donnell et al. [38] | 1994 | 4 years (2–10) | 60 | Curettage +PMMA Curettage + PMMA + burr |
42% 17% |
0% | Tumor extension Pathological fracture Location Burr |
| Prosser et al. [40] | 2005 | 70 months (24–214) | 137 | Curettage + burring | 19% | 1.6% | Tumor extension |
| Saiz et al. [43] | 2004 | 76 months (26–178) | 40 | Curettage + burr + PMMA + phenol | 13% | NR | None |
| Su et al. [45] | 2004 | 62 months (28–138) | 87 | Wide resection Curettage + burr + phenol |
3% 18% |
1.2% | Surgical margin |
| Trieb et al. [47] | 2001 | 11 years (4–43) | 47 | Curettage + burr Curettage + burr + phenol |
21% 25% |
0% | None |
| Turcotte et al. [50] | 2002 | 60 months (24–192) | 156 | Wide resection Curettage +/− burring +/− PMMA +/− phenol |
16%* 18%* |
NR | None |
| Current study | 2010 | 108 months (36–233) | 118 | Wide resection Curettage + burr Curettage + burr + phenol Curettage + burr + PMMA + phenol |
5% 32% 34% 15% |
4.2% | Surgical margin PMMA Age |
* Data include patients treated for recurrent GCT; NR = not reported.