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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Immunogenetics. 2010 Sep 2;62(10):701–707. doi: 10.1007/s00251-010-0473-9

Fig. 1. Breadth and frequency of anamnestic SIV-specific CD4+ T-cell responses.

Fig. 1

The breath of SIV-specific CD8-depleted PBMC responses present in five vaccinated animals that controlled viral replication targeted mainly SIV Gag during the peak of viremia after SIVmE660 challenge (A) (Wilson et al. 2009). Some of the responses detected during the peak of viremia were still present in the chronic phase of infection (six months post-infection) (B). Several of the highest frequency responses in CD8-depleted PBMC from vaccinated animals that controlled viral replication were directed against the Gag G peptide-pool (amino acids 241-291), located within the SIV Capsid (Gag-p27), during the chronic phase of infection (C). A “+” sign in panel (C) represents an anamnestic IFNγ positive CD8-depleted PBMC response detected against a particular region of Gag. The SIV-specific CD4+ T-cell responses directed against the Gag G peptide-pool (amino acids 241-291) located within SIV Capsid (Gag-p27) are shown underlying or overlying the amino acid sequence (D). The bars in panels (A), (B) and (C) represent the mean and the standard deviation