Fig. 2.

a Percentage of apoptotic leukemic cells in cultures treated with resveratrol, fludarabine, and resveratrol combined with fludarabine for 24 h and the CI calculated for each sample. b Percentage of apoptotic leukemic cells in cultures treated with resveratrol, cladribine, and resveratrol combined with cladribine for 24 h and the CI calculated for each sample. Data represent the drug-induced increase in the percentage of apoptotic cells compared to the respective values observed in parallel control cultures. CI = (sum of specific apoptosis of single agent treatment/specific apoptosis of combined treatment). The percentage of specific apoptosis was determined using the following formula: specific apoptosis = (drug induced apoptosis − spontaneous apoptosis)/(100 − spontaneous apoptosis) × 100%. When CI < 1, CI = 1, and CI > 1, the effects were defined as synergistic, additive, and infra-additive, respectively