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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Oct 14;20(24):7385–7387. doi: 10.1016/j.bmcl.2010.10.038

Table 1.

Anticancer activity of retinoid-chalcone derivatives against HT-29 cells.

graphic file with name nihms246651t1.jpg
Compound R1 R2 R3 IC50 ± SD (µM)*
5 3.70 ± 0.21
6 H CN H 1.94 ± 0.57
7 H H H 2.86 ± 1.09
8 CN H H 0.66 ± 0.25
9 H OCH3 H 4.13 ± 1.06
10 H CF3 H 2.83 ± 0.35
11 H Br H 5.02 ± 0.17
12 H NO2 H 1.46 ± 0.22
13 H N(CH3)2 H 6.59 ± 0.33
14 OH H H 2.66 ± 0.43
15 NH2 H H 6.99 ± 1.22
16 H OCH2CHC(CH3)2 H 13.33 ± 1.40
17 OCH2CHC(CH3)2 H H 3.73 ± 0.07
18 OCH3 H OCH3 1.54 ± 0.16
19 OCH3 OCH3 H 8.32 ± 1.59
20 NO2 H H 1.45 ± 0.04
21 H 5-1H tetrazole H 23.52 ± 1.00
22 Cl Cl H 8.12 ± 0.27
23 OH OCH3 H 1.59 ± 0.14
*

The experiments were performed twice and the average values were obtained from two independent experiments