Table 1.
Physical and chemical properties and pharmacokinetics of Gd micelles
Formulation | Size, nm | r1, 60 MHz (s−1 mM−1) | Blood half-life, h | %ID in liver of apoE−/− mice at 24 h | |
---|---|---|---|---|---|
apoE−/− mice | Wild-type mice | ||||
MDA2-micelles | 22 ± 2 | 9.3 | 14.3* | 1.7 | 18 ± 4 |
IK17-micelles | 16 ± 3 | 10.5 | 16.5* | 1.8 | 18 ± 4 |
E06-micelles | 16 ± 3 | 10.8 | 20.1* | 1.7 | 32 ± 2 |
IgG-micelles | 16 ± 4 | 10.4 | 1.4 | 1.3 | 18 ± 3 |
Untargeted micelles | 14 ± 2 | 11.6 | 1.5 | 1.5 | 12 ± 3 |
*P < 0.001 compared to wild-type mice